Of course! The frame is your foundation, and you can purchase wire or wooden ones from your local florist. Ask them for some bind wire too, so that you can secure your sprigs into place as you go, and then the rest is up to your creativity.
These days, wreaths range from loose and wild to dense and full, so do some research first, be it on Pinterest or magazine mood boarding to see which style you like most. Collecting materials and perhaps laying them out around the base can be helpful in deciding your design direction. Also, look at which additions you might like to incorporate, such as rustic bells, dried seed heads, and ribbons. These help to personalise your wreath to your home.